Meet the Researcher

Dr Dongang Wang

The University of Sydney , NSW

Dr Dongang Wang is a research fellow at the Brain and Mind Centre at The University of Sydney. 

With a specialisation in neuroimaging analysis, Dr Wang is interested in combining deep learning technologies and magnetic resonance imaging (MRI) scans to improve how disease progression in multiple sclerosis (MS) can be predicted. 

Dr Wang hopes to develop a tool that can be easily implemented into clinical workflows, to facilitate early tailored treatment and improve long-term clinical outcomes.  

About Dr Dongang Wang

TELL US AN INTERESTING FACT ABOUT YOURSELF
I enjoy reading, cooking, and DIY projects, and I've been combining these activities to spend quality time with my family. I have a deep appreciation for culture and history, reflecting my interest in the past, while my research focuses on the future with artificial intelligence and medical imaging.
WHAT INSPIRED YOU TO GET INVOLVED IN MS RESEARCH?
I started working in neuroimaging analysis engineering after my master's degree in artificial intelligence and discovered its value in quantitative analysis for brain research and disease diagnosis. Realising the potential to apply my expertise in AI to this field, I saw an opportunity to make a real-world impact and help people. Growing up in a family of doctors, researching MS and other neurodegenerative diseases helped bridge my knowledge with my family's dedication to healthcare.
WHAT DO YOU THINK HAS BEEN THE MOST EXCITING DEVELOPMENT IN MS RESEARCH?
One of the most exciting developments in MS research is the application of AI in assisted diagnosis and patient monitoring. Recent breakthroughs have shown that monitoring brain and lesion changes can significantly improve patient status assessment and treatment decisions. The next step, which aligns with my current research project, is to predict disease progression using patient records. This advancement holds great potential for early intervention and personalised treatment strategies, important to MS patient care
TELL US ABOUT YOUR CURRENT RESEARCH PROJECT
My current research project aims to utilise the recently developed and popular AI technique, large language models (LLMs), to advance the prediction of disease progression in MS, focusing on electronic health records (EHR) and neuroimaging. This study seeks to explore, validate, and apply LLMs in a clinical setting to evaluate their predictive performance and analyse findings to identify novel biomarkers or clinical indicators of rapid disease progression.
WHY IS YOUR RESEARCH IMPORTANT AND HOW WILL IT INFLUENCE THE UNDERSTANDING AND TREATMENT OF MS?
Recent progress in deep learning and AI has already offered promising pathways to better understand MS, such as through quantitative analysis of MS lesions and their activities in longitudinal studies. My research builds on this by leveraging cutting-edge AI techniques like LLMs to identify additional factors or biomarkers relevant to disease progression. This could contribute to early intervention strategies and personalised treatments, ultimately enhancing patient outcomes and advancing our overall understanding of MS.
WHAT DO YOU ENJOY MOST ABOUT WORKING IN THE LAB AND WHAT ARE SOME OF THE CHALLENGES YOU FACE?
  I enjoy working on algorithms and pushing their performance forward, especially when achieving state-of-the-art results in classification, segmentation, and prediction tasks. The challenges can be daunting, as algorithm performance is influenced by multiple factors such as imaging quality, hyperparameters, data bias, and pre- and post-processing. However, my sense of accomplishment upon solving these complex issues is immensely rewarding.
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Dongang Wang