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MS is a disease impacting the brain and spinal cord, leading to noticeable changes in cognitive functions in up to 65% of individuals. These changes involve issues with memory recall, problem-solving abilities, and processing speed, significantly impacting daily tasks like work and social interactions. Detecting these subtle cognitive shifts within an MS clinic setting proves challenging, as current testing methods are time-consuming and inadequate for tracking gradual changes over time.Â
A research initiative has been undertaken by Dr Daniel Merlo and his team to leverage an established computerised testing system, called MSReactor. This test measures the speed of thinking, attention and memory in people with MS. The goal is to monitor long-term cognitive fluctuations commonly observed in individuals with MS. This endeavour seeks to define alterations detected by these tests that hold clinical significance, linking them to the worsening of other MS symptoms and hindrances in daily tasks, such as work productivity.Â
Developing and validating tests capable of measuring these nuanced cognitive changes among people with MS could provide neurologists with invaluable insights. This deeper understanding could empower them to make more informed decisions regarding clinical care, fostering a collaborative approach to managing MS.Â
Dr Merlo and his team found that even after three years of testing, the acceptability of the MSReactor computerised test is still high. Â
The MSReactor tests can predict persistent increases in disability. Early analyses showed MSReactor can predict future increases in disability with high accuracy. Early analyses also showed that MSReactor tests could predict impairment in cognition with high accuracy. More study participants are needed for the final analyses later this year, with final data collection expected in July/August of 2024.Â
Dr Merlo and his team found that feeling anxious while completing the tests or having higher levels of self-reported depression may lead some people with MS to want to stop testing or not enjoy the testing. This is an important finding, as more support can be provided within clinics to ease people’s anxiety around testing and to encourage continued testing.Â
Dr Merlo and his team have also been working with experts from Monash University and developed a new artificial intelligence model that can use clinical information as well as information from MSReactor tests to predict disability worsening.Â
Updated 31 March 2024Â
Updated: 14 February, 2022
Laboratory research that investigates scientific theories behind the possible causes, disease progression, ways to diagnose and better treat MS.
Research that builds on fundamental scientific research to develop new therapies, medical procedures or diagnostics and advances it closer to the clinic.
Clinical research is the culmination of fundamental and translational research turning those research discoveries into treatments and interventions for people with MS.
$225,000
3 years
